En davg, NMR and HDL-C is not substantially different from zero. Descriptive statistics for the HDL-C/ApoA-I ratios corresponding to every single discrete value of davg, NMR are provided in Table two. As davg, NMR increases over the observed range (eight.0 to 10.8 nm), the median (and mean) HDL-C/ApoA-I ratio increases practically two-fold from 0.267 to 0.523; the corresponding CV values with the HDL-C/ApoA-I ratios differ between 9.six and 16 .*In reference 18, NMR lipoprotein profiles were reported when it comes to the concentrations of compact, medium and huge HDL particles. The corresponding typical HDL sizes obtained in that study have been kindly supplied for the authors by Dr. David Kallend, from data on file at F. Hoffmann-La Roche Ltd.Clin Chem. Author manuscript; obtainable in PMC 2014 June 01.Mazer et al.PageFig. 1 gives a graphical representation of the experimental partnership involving the HDL diameter (davg, NMR) and HDL-C/ApoA-I ratio in the 26,772 WHS subjects employing a mixture scatter plot/heat map. Individual data points in the scatter plot fall on parallel horizontal lines, corresponding to davg, NMR values of 8.0, eight.1, 8.2, …, ten.8 nm. Since several data points overlap, a heat map was used to indicate the density of information points in little rectangular regions of the scatter plot.Price of N-Methyltetrahydro-2H-pyran-4-amine The “hottest” region, i.Buy1622303-50-7 e.PMID:24883330 , greatest density of points, corresponds to the pink/red “cigar shape” inside the bigger “cloud” of information points and exhibits a constructive slope. The median HDL-C/ApoA-I ratios and inter-quartile ranges (IQR) for information points using the very same worth of davg, NMR (Table two), indicated by the diamonds and horizontal line segments, fall inside the “cigar shape” area of your heat map and extend into the “cooler” area exactly where davg, NMR exceeds 10.1 nm. The least squares regression line with the HDL-C/ApoA-I ratios vs. davg, NMR, also shown in Fig. 1, is discussed later. Comparison of Theoretical and Experimental Relationships amongst HDL Size and HDL-C/ ApoA-I Ratio Fig. 2 superimposes the household of theoretical curves derived in the updated Shen model (Supplemental Information, Fig. S4) onto the scatter plot/heat map shown in Fig. 1. For the literature-based ranges of your parameters TG/CEcore (0 ?0.4) and FApoA-I (50 ?90 ) applied within the model calculations, the theoretical curves are in affordable quantitative agreement with the WHS information, yielding comparable sizes and bracketing the “cigar shape” region of the heat map. The two curves defined by the parameter sets TG/CEcore = 0; FApoA-I = 70 and TG/CEcore = 0.133; FApoA-I = 60 lie closest to the center of your “cigar shape” region and possess a related orientation. Theoretical curves with larger values of TG/CEcore (0.two) or FApoA-I (70 ) are shifted to the left with the “cigar-shape” area; when curves with a decrease worth of FApoA-I (50 ) are shifted for the ideal. It must be appreciated that the theoretical curves shown in Fig. two have been derived independently on the WHS data, with parameter values thatwere taken from the literature, rather than estimated by curve fitting (see Supplemental Data, Table S1). Use of Regression Equation to Estimate HDL Size in the HDL-C/ApoA-I Ratio in States of CETP Deficiency and Pharmacological Inhibition In contrast to the theoretical curves, the least squares regression line shown in Fig. 1 was empirically derived by fitting the WHS data. It passes closely towards the median HDL-C/ApoA-I values within the “cigar-shape” region, deviating slightly for the left at HDL sizes above ten.3 nm, where the data.
