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Matsuzaki et al. BMC Complementary and Alternative Medicine 2013, 13:370 http://biomedcentral/1472-6882/13/RESEARCH ARTICLEOpen AccessAntidepressant-like effects of a water-soluble extract in the culture medium of Ganoderma lucidum mycelia in ratsHirokazu Matsuzaki1, Yuta Shimizu1, Naohiro Iwata2, Shinya Kamiuchi2, Fumiko Suzuki3, Hiroshi Iizuka3, Yasuhide Hibino2 and Mari Okazaki1*AbstractBackground: Ganoderma lucidum is often a well-liked medicinal mushroom made use of for advertising well being and longevity in Asian cou.